Anti-ACKR1 antibody (1-50 aa) (STJ92785)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DARC at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Atypical chemokine receptor 1 (1-50 aa) for use in IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACKR1 |
| Gene ID | 2532 |
| Uniprot ID | ACKR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DARC at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | Duffy Polyclonal Antibody detects endogenous levels of Duffy protein. |
Additional Info
| Post Translational Modifications | Sulfation at Tyr-41 facilitates interaction with MGSA/CXCL1, RANTES/CCL5 and MCP-1/CCL2 but not IL8/CXCL8. Sulfation at Tyr-30 facilitates interaction with IL8/CXCL8. (Microbial infection) Sulfation at Tyr-41 facilitates interaction with Plasmodium vivax Duffy receptor (PVDR). Sulfation at Tyr-30/Tyr-41 and Tyr-41 alone increases binding affinity of Plasmodium vivax parasites and likely promotes invasion of red blood cells. (Microbial infection) Sulfation at Tyr-41 facilitates interaction with Plasmodium knowlesi Duffy receptor alpha form (DBPalpha). Sulfation at Tyr-30/Tyr-41 and Tyr-41 alone increases binding affinity of Plasmodium knowlesi parasites and likely promotes invasion of red blood cells. |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes.when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium vivax. (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi. |
| Protein Name | Atypical Chemokine Receptor 1Duffy Antigen Receptor For ChemokinesDuffy Antigen/Chemokine ReceptorDuffy Blood Group AntigenFy GlycoproteinGpfyGlycoprotein DPlasmodium Vivax ReceptorCd Antigen Cd234 |
| Database Links | Reactome: R-HSA-375276 |
| Cellular Localisation | Early EndosomeRecycling EndosomeMembraneMulti-Pass Membrane ProteinPredominantly Localizes To Endocytic VesiclesAnd Upon Stimulation By The Ligand Is Internalized Via CaveolaeOnce InternalizedThe Ligand Dissociates From The ReceptorAnd Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane |
| Alternative Antibody Names | Anti-Atypical Chemokine Receptor 1 antibodyAnti-Duffy Antigen Receptor For Chemokines antibodyAnti-Duffy Antigen/Chemokine Receptor antibodyAnti-Duffy Blood Group Antigen antibodyAnti-Fy Glycoprotein antibodyAnti-Gpfy antibodyAnti-Glycoprotein D antibodyAnti-Plasmodium Vivax Receptor antibodyAnti-Cd Antigen Cd234 antibodyAnti-ACKR1 antibodyAnti-DARC antibodyAnti-FY antibodyAnti-GPD antibody |
Information sourced from Uniprot.org