| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Acinus (N-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACIN1 |
| Gene ID: |
22985 |
| Uniprot ID: |
ACINU_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
Reacts with the N-terminus of human Acinus protein. |
| Immunogen: |
Synthetic peptide corresponding to amino acids from the N-terminal region of human Acinus protein |
| Post Translational Modifications | Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1. Undergoes proteolytic cleavage.the processed form is active, contrary to the uncleaved form. |
| Function | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets.ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes).specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S).the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. |
| Protein Name | Apoptotic Chromatin Condensation Inducer In The NucleusAcinus |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleNucleoplasmPhosphorylation On Ser-1180 By Srpk2 Redistributes It From The Nuclear Speckles To The Nucleoplasm |
| Alternative Antibody Names | Anti-Apoptotic Chromatin Condensation Inducer In The Nucleus antibodyAnti-Acinus antibodyAnti-ACIN1 antibodyAnti-ACINUS antibodyAnti-KIAA0670 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
