Anti-Acetyl-H2AZ1-K5 antibody (1-50 aa) (STJ90117)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Histone H2A around the acetylated site of Lys5 at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Acetyl-Histone H2A.Z-K5 (1-50 aa) for use in IHC, IF, WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | H2AZ1 |
| Gene ID | 3015 |
| Uniprot ID | H2AZ_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Histone H2A around the acetylated site of Lys5 at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | Acetyl-Histone H2A (K5) Polyclonal Antibody detects endogenous levels of Histone H2A protein only when acetylated at K5. |
Additional Info
| Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. |
| Protein Name | Histone H2a.zH2a/Z |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone H2a.z antibodyAnti-H2a/Z antibodyAnti-H2AZ1 antibodyAnti-H2AFZ antibodyAnti-H2AZ antibody |
Information sourced from Uniprot.org