| Background | Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of macromolecule metabolic process; and positive regulation of dendrite development. Located in cytoplasm and nucleus. Used to study endometriosis. Biomarker of leiomyoma; non-alcoholic fatty liver disease; and pancreatic cancer. Human ortholog (s) of this gene implicated in Weaver syndrome; bone cancer (multiple) ; gastrointestinal system cancer (multiple) ; hematologic cancer (multiple) ; and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). |
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