| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Acetyl-Cyclin-dependent kinase inhibitor 1C-Lys278 (241-290 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDKN1C |
| Gene ID: | 1028 |
| Uniprot ID: | CDN1C_HUMAN |
| Immunogen Region: | 241-290 aa |
| Specificity: | Acetyl-p57 (K278) Polyclonal Antibody detects endogenous levels of p57 protein only when acetylated at K278. |
| Immunogen: | The antiserum was produced against synthesized Acetyl-peptide derived from the human p57Kip2 around the Acetylation site of Lys278 at the amino acid range 241-290 |
| Function | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 1cCyclin-Dependent Kinase Inhibitor P57P57kip2 |
| Database Links | Reactome: R-HSA-69231Reactome: R-HSA-9661069 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 1c antibodyAnti-Cyclin-Dependent Kinase Inhibitor P57 antibodyAnti-P57kip2 antibodyAnti-CDKN1C antibodyAnti-KIP2 antibody |
Information sourced from Uniprot.org
