Anti-ACER3 antibody (171-220 aa) (STJ91628)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PHCA at the amino acid range 171-220
General Information
| Short Description | Rabbit polyclonal anti-Alkaline ceramidase 3 (171-220 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACER3 |
| Gene ID | 55331 |
| Uniprot ID | ACER3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PHCA at the amino acid range 171-220 |
| Immunogen Region | 171-220 aa |
| Specificity | APHC Polyclonal Antibody detects endogenous levels of APHC protein. |
Additional Info
| Function | Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response. |
| Protein Name | Alkaline Ceramidase 3Alkcdase 3Alkaline Cdase 3Alkaline Dihydroceramidase Sb89Alkaline PhytoceramidaseAphc |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Alkaline Ceramidase 3 antibodyAnti-Alkcdase 3 antibodyAnti-Alkaline Cdase 3 antibodyAnti-Alkaline Dihydroceramidase Sb89 antibodyAnti-Alkaline Phytoceramidase antibodyAnti-Aphc antibodyAnti-ACER3 antibodyAnti-APHC antibodyAnti-PHCA antibody |
Information sourced from Uniprot.org