Host: |
Rabbit |
Applications: |
WB/IHC/IF/ELISA |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Alkaline ceramidase 3 (171-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
ACER3 |
Gene ID: |
55331 |
Uniprot ID: |
ACER3_HUMAN |
Immunogen Region: |
171-220 aa |
Specificity: |
APHC Polyclonal Antibody detects endogenous levels of APHC protein. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from the human PHCA at the amino acid range 171-220 |
Function | Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response. |
Protein Name | Alkaline Ceramidase 3Alkcdase 3Alkaline Cdase 3Alkaline Dihydroceramidase Sb89Alkaline PhytoceramidaseAphc |
Database Links | Reactome: R-HSA-9845614 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
Alternative Antibody Names | Anti-Alkaline Ceramidase 3 antibodyAnti-Alkcdase 3 antibodyAnti-Alkaline Cdase 3 antibodyAnti-Alkaline Dihydroceramidase Sb89 antibodyAnti-Alkaline Phytoceramidase antibodyAnti-Aphc antibodyAnti-ACER3 antibodyAnti-APHC antibodyAnti-PHCA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance