Anti-ACER1 antibody (100-180 aa) (STJ97625)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from ASAH3 at the amino acid range 100-180
General Information
| Short Description | Rabbit polyclonal anti-Alkaline ceramidase 1 (100-180 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACER1 |
| Gene ID | 125981 |
| Uniprot ID | ACER1_HUMAN |
| Immunogen | Synthesized peptide derived from ASAH3 at the amino acid range 100-180 |
| Immunogen Region | 100-180 aa |
| Specificity | ASAH3 Polyclonal Antibody detects endogenous levels of ASAH3 protein. |
Additional Info
| Function | Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide. May also hydrolyze dihydroceramides to produce dihydrosphingosine. ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis. |
| Protein Name | Alkaline Ceramidase 1Alkcdase 1Alkaline Cdase 1Acylsphingosine Deacylase 3N-Acylsphingosine Amidohydrolase 3 |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Alkaline Ceramidase 1 antibodyAnti-Alkcdase 1 antibodyAnti-Alkaline Cdase 1 antibodyAnti-Acylsphingosine Deacylase 3 antibodyAnti-N-Acylsphingosine Amidohydrolase 3 antibodyAnti-ACER1 antibodyAnti-ASAH3 antibody |
Information sourced from Uniprot.org