Anti-ACAP1 antibody (20-230 aa) (STJ11106182)

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STJ11106182
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: ACAP1
Gene ID: 9744
Uniprot ID: ACAP1_HUMAN
Immunogen Region: 20-230 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human ACAP1 (NP_055531.1).
Immunogen Sequence: SIELVEAEVSELETRLEKLL KLGTGLLESGRHYLAASRAF VVGICDLARLGPPEPMMAEC LEKFTVSLNHKLDSHAELLD ATQHTLQQQIQTLVKEGLRG FREARRDFWRGAESLEAALT HNAEVPRRRAQEAEEAGAAL RTARAGYRGRALDYALQINV IEDKRKFDIMEFVLRLVEAQ ATHFQQGHEELSRLSQYRKE LGAQLHQLVLN
Tissue Specificity Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
Post Translational Modifications Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Function GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Protein Name Arf-Gap With Coiled-Coil - Ank Repeat And Ph Domain-Containing Protein 1
Centaurin-Beta-1
Cnt-B1
Cellular Localisation Recycling Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Arf-Gap With Coiled-Coil - Ank Repeat And Ph Domain-Containing Protein 1 antibody
Anti-Centaurin-Beta-1 antibody
Anti-Cnt-B1 antibody
Anti-ACAP1 antibody
Anti-CENTB1 antibody
Anti-KIAA0050 antibody

Information sourced from Uniprot.org

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