| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ACAP1 |
| Gene ID: |
9744 |
| Uniprot ID: |
ACAP1_HUMAN |
| Immunogen Region: |
20-230 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human ACAP1 (NP_055531.1). |
| Immunogen Sequence: |
SIELVEAEVSELETRLEKLL KLGTGLLESGRHYLAASRAF VVGICDLARLGPPEPMMAEC LEKFTVSLNHKLDSHAELLD ATQHTLQQQIQTLVKEGLRG FREARRDFWRGAESLEAALT HNAEVPRRRAQEAEEAGAAL RTARAGYRGRALDYALQINV IEDKRKFDIMEFVLRLVEAQ ATHFQQGHEELSRLSQYRKE LGAQLHQLVLN |
| Tissue Specificity | Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. |
| Post Translational Modifications | Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. |
| Function | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. |
| Protein Name | Arf-Gap With Coiled-Coil - Ank Repeat And Ph Domain-Containing Protein 1Centaurin-Beta-1Cnt-B1 |
| Cellular Localisation | Recycling Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Arf-Gap With Coiled-Coil - Ank Repeat And Ph Domain-Containing Protein 1 antibodyAnti-Centaurin-Beta-1 antibodyAnti-Cnt-B1 antibodyAnti-ACAP1 antibodyAnti-CENTB1 antibodyAnti-KIAA0050 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
