| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ACACB |
| Gene ID: |
32 |
| Uniprot ID: |
ACACB_HUMAN |
| Immunogen Region: |
2300-2400 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 2300-2400 of human ACACB (NP_001084.3). |
| Immunogen Sequence: |
FHDTPGRMLEKGVISDILEW KTARTFLYWRLRRLLLEDQV KQEILQASGELSHVHIQSML RRWFVETEGAVKAYLWDNNQ VVVQWLEQHWQAGDGPRSTI R |
| Tissue Specificity | Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon. Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis. |
| Post Translational Modifications | The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. Phosphorylation at Ser-222 by AMPK inactivates the enzyme. Required for the maintenance of skeletal muscle lipid and glucose homeostasis. |
| Function | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism. Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation. Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage. |
| Protein Name | Acetyl-Coa Carboxylase 2Acc-Beta |
| Database Links | Reactome: R-HSA-163765Reactome: R-HSA-196780Reactome: R-HSA-200425Reactome: R-HSA-2426168 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Acetyl-Coa Carboxylase 2 antibodyAnti-Acc-Beta antibodyAnti-ACACB antibodyAnti-ACC2 antibodyAnti-ACCB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
