| Tissue Specificity | Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level). |
| Function | Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion. |
| Protein Name | 1-Acylglycerol-3-Phosphate O-Acyltransferase Abhd5Abhydrolase Domain-Containing Protein 5Lipid Droplet-Binding Protein Cgi-58 |
| Database Links | Reactome: R-HSA-163560 |
| Cellular Localisation | CytoplasmLipid DropletCytosolColocalized With Plin And Adrp On The Surface Of Lipid DropletsThe Localization Is Dependent Upon The Metabolic Status Of The Adipocytes And The Activity Of Pka |
| Alternative Antibody Names | Anti-1-Acylglycerol-3-Phosphate O-Acyltransferase Abhd5 antibodyAnti-Abhydrolase Domain-Containing Protein 5 antibodyAnti-Lipid Droplet-Binding Protein Cgi-58 antibodyAnti-ABHD5 antibodyAnti-NCIE2 antibodyAnti-CGI-58 antibody |
Information sourced from Uniprot.org
