| Tissue Specificity | Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart. |
| Function | Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration. |
| Protein Name | Monoacylglycerol Lipase Abhd22-Arachidonoylglycerol HydrolaseAbhydrolase Domain-Containing Protein 2AcetylesteraseLung Alpha/Beta Hydrolase 2Mmlabh2Triacylglycerol Lipase |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosome MembraneAbsent From The Sperm Flagellum |
| Alternative Antibody Names | Anti-Monoacylglycerol Lipase Abhd2 antibodyAnti-2-Arachidonoylglycerol Hydrolase antibodyAnti-Abhydrolase Domain-Containing Protein 2 antibodyAnti-Acetylesterase antibodyAnti-Lung Alpha/Beta Hydrolase 2 antibodyAnti-Mmlabh2 antibodyAnti-Triacylglycerol Lipase antibodyAnti-Abhd2 antibodyAnti-Labh-2 antibodyAnti-Labh2 antibody |
Information sourced from Uniprot.org
