| Post Translational Modifications | Ubiquitinated by CNOT4. Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy. |
| Function | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. |
| Protein Name | Atp-Binding Cassette Sub-Family E Member 12'-5'-Oligoadenylate-Binding ProteinHuhp68Rnase L InhibitorRibonuclease 4 InhibitorRns4i |
| Database Links | Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family E Member 1 antibodyAnti-2'-5'-Oligoadenylate-Binding Protein antibodyAnti-Huhp68 antibodyAnti-Rnase L Inhibitor antibodyAnti-Ribonuclease 4 Inhibitor antibodyAnti-Rns4i antibodyAnti-ABCE1 antibodyAnti-RLI antibodyAnti-RNASEL1 antibodyAnti-RNASELI antibodyAnti-RNS4I antibodyAnti-OK antibodyAnti-SW-cl.40 antibody |
Information sourced from Uniprot.org
