| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ABCD3 (600-659 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | ABCD3 |
| Gene ID: | 5825 |
| Uniprot ID: | ABCD3_HUMAN |
| Immunogen Region: | 600-659 aa |
| Specificity: | Specific for ABCD3. |
| Immunogen: | A synthetic peptide from aa region 600-659 of human ABCD3 conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 370 Kda Peroxisomal Membrane ProteinPmp70 |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 3 antibodyAnti-70 Kda Peroxisomal Membrane Protein antibodyAnti-Pmp70 antibodyAnti-ABCD3 antibodyAnti-PMP70 antibodyAnti-PXMP1 antibody |
Information sourced from Uniprot.org