Anti-ABCD1 antibody (531-580 aa) (STJ91414)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ABCD1 at the amino acid range 531-580
General Information
| Short Description | Rabbit polyclonal anti-ATP-binding cassette sub-family D member 1 (531-580 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCD1 |
| Gene ID | 215 |
| Uniprot ID | ABCD1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ABCD1 at the amino acid range 531-580 |
| Immunogen Region | 531-580 aa |
| Specificity | ABCD1 Polyclonal Antibody detects endogenous levels of ABCD1 protein. |
Additional Info
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes.namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 1Adrenoleukodystrophy ProteinAldp |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-390247Reactome: R-HSA-5684045Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane ProteinMitochondrion MembraneLysosome MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 1 antibodyAnti-Adrenoleukodystrophy Protein antibodyAnti-Aldp antibodyAnti-ABCD1 antibodyAnti-ALD antibody |
Information sourced from Uniprot.org