| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCC6 (825-875 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
ABCC6 |
| Gene ID: |
368 |
| Uniprot ID: |
MRP6_HUMAN |
| Immunogen Region: |
825-875 aa |
| Specificity: |
Specific for ABCC6. |
| Immunogen: |
A synthetic peptide from aa region 825-875 of human ABCC6 conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Glycosylated. |
| Function | Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 6Anthracycline Resistance-Associated ProteinMulti-Specific Organic Anion Transporter EMoat-EMultidrug Resistance-Associated Protein 6 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5690338 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinLocalized To The Basal Membrane Of Sertoli CellsIsoform 1: Basolateral Cell MembraneIsoform 2: Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 6 antibodyAnti-Anthracycline Resistance-Associated Protein antibodyAnti-Multi-Specific Organic Anion Transporter E antibodyAnti-Moat-E antibodyAnti-Multidrug Resistance-Associated Protein 6 antibodyAnti-ABCC6 antibodyAnti-ARA antibodyAnti-MRP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
