• STJ70611 (4µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

Anti-ABCC4/MRP4 antibody (C-Term) (STJ70611)

SKU:
STJ70611-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ABCC4/MRP4 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-Recommended concentration, 4-6µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ABCC4
Gene ID: 10257
Uniprot ID: MRP4_HUMAN
Immunogen Region: C-Term
Accession Number: NP_005836.2
Specificity: This antibody is expected to recognize isoform 1 (NP_005836.2) only.
Immunogen Sequence: CNGQPSTLTIFETAL
Post Translational Modifications N-glycosylated.leading to substrate-selective effects on its transport activity.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
Protein Name Atp-Binding Cassette Sub-Family C Member 4
Mrp/Cmoat-Related Abc Transporter
Multi-Specific Organic Anion Transporter B
Moat-B
Multidrug Resistance-Associated Protein 4
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-382556
Reactome: R-HSA-9748787
Reactome: R-HSA-9753281
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Its Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 4 antibody
Anti-Mrp/Cmoat-Related Abc Transporter antibody
Anti-Multi-Specific Organic Anion Transporter B antibody
Anti-Moat-B antibody
Anti-Multidrug Resistance-Associated Protein 4 antibody
Anti-ABCC4 antibody
Anti-MOATB antibody
Anti-MRP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance