| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 3 Canalicular Multispecific Organic Anion Transporter 2Multidrug Resistance-Associated Protein 3 |
| Database Links | Reactome: R-MMU-159418Reactome: -MMU-382556Reactome: -MMU-9749641Reactome: -MMU-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 3 antibodyAnti-Canalicular Multispecific Organic Anion Transporter 2 antibodyAnti-Multidrug Resistance-Associated Protein 3 antibodyAnti-Abcc3 antibodyAnti-Cmoat2 antibodyAnti-Mrp3 antibody |
Information sourced from Uniprot.org
