| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCC3 (850-900 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Abcc3 |
| Gene ID: |
76408 |
| Uniprot ID: |
MRP3_MOUSE |
| Immunogen Region: |
850-900 aa |
| Specificity: |
Specific for ABCC3. |
| Immunogen: |
A synthetic peptide from aa region 850-900 of mouse ABCC3 conjugated to blue carrier protein was used as the antigen. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 3 Canalicular Multispecific Organic Anion Transporter 2Multidrug Resistance-Associated Protein 3 |
| Database Links | Reactome: R-MMU-159418Reactome: -MMU-382556Reactome: -MMU-9749641Reactome: -MMU-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 3 antibodyAnti-Canalicular Multispecific Organic Anion Transporter 2 antibodyAnti-Multidrug Resistance-Associated Protein 3 antibodyAnti-Abcc3 antibodyAnti-Cmoat2 antibodyAnti-Mrp3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
