Anti-ABCC10 antibody (835-884) (STJ94207)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MRP7. AA range:835-884
General Information
| Short Description | Rabbit polyclonal anti-ATP-binding cassette sub-family C member 10 (835-884) for use in WB and IHC in Human and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCC10 |
| Gene ID | 89845 |
| Uniprot ID | MRP7_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MRP7. AA range:835-884 |
| Immunogen Region | 835-884 |
| Specificity | MRP7 Polyclonal Antibody detects endogenous levels of MRP7 protein. |
Additional Info
| Tissue Specificity | In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. Isoform 1: Specifically expressed in spleen. Isoform 2: Widely expressed. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 10Multidrug Resistance-Associated Protein 7 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneBasal Cell MembraneLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 10 antibodyAnti-Multidrug Resistance-Associated Protein 7 antibodyAnti-ABCC10 antibodyAnti-MRP7 antibodyAnti-SIMRP7 antibody |
Information sourced from Uniprot.org