| Function | Exports glutathione-coordinated iron-sulfur clusters such as 2Fe-2S-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis. |
| Protein Name | Iron-Sulfur Clusters Transporter Abcb7 - MitochondrialAtp-Binding Cassette Sub-Family B Member 7 - MitochondrialAtp-Binding Cassette Transporter 7Abc Transporter 7 Protein |
| Database Links | Reactome: R-HSA-1369007Reactome: R-HSA-2564830 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Iron-Sulfur Clusters Transporter Abcb7 - Mitochondrial antibodyAnti-Atp-Binding Cassette Sub-Family B Member 7 - Mitochondrial antibodyAnti-Atp-Binding Cassette Transporter 7 antibodyAnti-Abc Transporter 7 Protein antibodyAnti-ABCB7 antibodyAnti-ABC7 antibody |
Information sourced from Uniprot.org
