| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCA7 (2010-2146) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCA7 |
| Gene ID: |
10347 |
| Uniprot ID: |
ABCA7_HUMAN |
| Immunogen Region: |
2010-2146 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2010-2146 of human ABCA7 (NP_061985.2). |
| Immunogen Sequence: |
QHLKGRFAAGHTLTLRVPAA RSQPAAAFVAAEFPGAELRE AHGGRLRFQLPPGGRCALAR VFGELAVHGAEHGVEDFSVS QTMLEEVFLYFSKDQGKDED TEEQKEAGVGVDPAPGLQHP KRVSQFLDDPSTAETVL |
| Tissue Specificity | Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Expressed in the hippocampus and the cerebellum. Isoform 2: Abundant in lymph node, spleen, thymus and trachea. Isoform 1: Strongly expressed in brain and bone marrow. |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylserine over phosphatidylcholine. Plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing. Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients. |
| Protein Name | Phospholipid-Transporting Atpase Abca7Abca-SsnAtp-Binding Cassette Sub-Family A Member 7Autoantigen Ss-NMacrophage Abc Transporter |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEarly Endosome MembraneCytoplasmCell ProjectionRuffle MembranePhagocytic CupLocalizes To Cell Membrane Ruffles And Phagocytic Cups Of Macrophages Stimulated With C1q Or Apoptotic CellsLocalizes To The Cytoplasm Of Resting MacrophagesProbably In Golgi And EndosomesLocalizes To The Apical Brush Border Of Cells In The Proximal Tubules Of KidneyIsoform 2: CytoplasmEndoplasmic ReticulumMay Localize To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Abca7 antibodyAnti-Abca-Ssn antibodyAnti-Atp-Binding Cassette Sub-Family A Member 7 antibodyAnti-Autoantigen Ss-N antibodyAnti-Macrophage Abc Transporter antibodyAnti-ABCA7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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