| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ABCA5 (450-550 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | ABCA5 |
| Gene ID: | 23461 |
| Uniprot ID: | ABCA5_HUMAN |
| Immunogen Region: | 450-550 aa |
| Specificity: | Specific for ABCA5. |
| Immunogen: | A synthetic peptide from aa region 450-550 of human ABCA5 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes. |
| Protein Name | Cholesterol Transporter Abca5Atp-Binding Cassette Sub-Family A Member 5 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinLysosome MembraneLate Endosome MembraneCell MembraneLocalized At Cell Membrane Under High Cholesterol Levels |
| Alternative Antibody Names | Anti-Cholesterol Transporter Abca5 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 5 antibodyAnti-ABCA5 antibodyAnti-KIAA1888 antibody |
Information sourced from Uniprot.org