| Function | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1. |
| Protein Name | Alanine--Trna Ligase - CytoplasmicAlanyl-Trna SynthetaseAlarsProtein Lactyltransferase Aars1Renal Carcinoma Antigen Ny-Ren-42 |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Nucleus In Response To Increased Levels Of LactateNuclear Translocation Is Dependent On Kpna4 |
| Alternative Antibody Names | Anti-Alanine--Trna Ligase - Cytoplasmic antibodyAnti-Alanyl-Trna Synthetase antibodyAnti-Alars antibodyAnti-Protein Lactyltransferase Aars1 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-42 antibodyAnti-AARS1 antibodyAnti-AARS antibody |
Information sourced from Uniprot.org
