Anti-AANAT antibody (STJA0010237)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SNAT
General Information
| Short Description | Rabbit polyclonal anti-Serotonin N-acetyltransferase for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AANAT |
| Gene ID | 15 |
| Uniprot ID | SNAT_HUMAN |
| Immunogen | Synthesized peptide derived from human SNAT |
| Specificity | This antibody detects endogenous levels of Human, Mouse, Rat SNAT |
Additional Info
| Tissue Specificity | Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. |
| Post Translational Modifications | cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins. |
| Function | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. |
| Protein Name | Serotonin N-AcetyltransferaseSerotonin AcetylaseAralkylamine N-AcetyltransferaseAa-Nat |
| Database Links | Reactome: R-HSA-209931 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serotonin N-Acetyltransferase antibodyAnti-Serotonin Acetylase antibodyAnti-Aralkylamine N-Acetyltransferase antibodyAnti-Aa-Nat antibodyAnti-AANAT antibodyAnti-SNAT antibody |
Information sourced from Uniprot.org