| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. |
| Protein Name | 5-Hydroxytryptamine Receptor 1d5-Ht-1d5-Ht1dSerotonin Receptor 1d |
| Database Links | Reactome: R-MMU-390666Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1d antibodyAnti-5-Ht-1d antibodyAnti-5-Ht1d antibodyAnti-Serotonin Receptor 1d antibodyAnti-Htr1d antibodyAnti-Gpcr14 antibody |
Information sourced from Uniprot.org
