| Host: | Guinea Pig |
| Applications: | IHC/WB |
| Reactivity: | Human/Marmoset/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Guinea Pig polyclonal anti-5HT1D R (C-Term) for use in IHC and WB in Human, Marmoset, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised |
| Purification: | Affinity purification |
| Dilution Range: | IHC, WB. A dilution of 1: 500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Htr1d |
| Gene ID: | 15552 |
| Uniprot ID: | 5HT1D_MOUSE |
| Immunogen Region: | C-Term |
| Specificity: | Specific for 5HT1D receptor. |
| Immunogen: | A synthetic peptide from c-terminal region of human 5HT1D receptor conjugated to blue carrier protein was used as the antigen. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. |
| Protein Name | 5-Hydroxytryptamine Receptor 1d5-Ht-1d5-Ht1dSerotonin Receptor 1d |
| Database Links | Reactome: R-MMU-390666Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1d antibodyAnti-5-Ht-1d antibodyAnti-5-Ht1d antibodyAnti-Serotonin Receptor 1d antibodyAnti-Htr1d antibodyAnti-Gpcr14 antibody |
Information sourced from Uniprot.org