Anti-5HT1D R antibody (C-Term) (STJ13100502)

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STJ13100502-100
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Host: Guinea Pig
Applications: IHC/WB
Reactivity: Human/Marmoset/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Guinea Pig polyclonal antibody anti-5HT1D R (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Formulation: Lyophilised
Purification: Affinity purification
Dilution Range: IHC, WB. A dilution of 1: 500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Htr1d
Gene ID: 15552
Uniprot ID: 5HT1D_MOUSE
Immunogen Region: C-Term
Specificity: Specific for 5HT1D receptor.
Immunogen: A synthetic peptide from c-terminal region of human 5HT1D receptor conjugated to blue carrier protein was used as the antigen.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Protein Name 5-Hydroxytryptamine Receptor 1d
5-Ht-1d
5-Ht1d
Serotonin Receptor 1d
Database Links Reactome: R-MMU-390666
Reactome: -MMU-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-5-Hydroxytryptamine Receptor 1d antibody
Anti-5-Ht-1d antibody
Anti-5-Ht1d antibody
Anti-Serotonin Receptor 1d antibody
Anti-Htr1d antibody
Anti-Gpcr14 antibody

Information sourced from Uniprot.org

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