| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-14-3-3 tau/YWHAQ (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 28kDa band observed in Human Brain (Hippocampus) lysates (calculated MW of 27.8kDa according to NP_006817.1). Recommended concentration: 0.03-0.1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | YWHAQ |
| Gene ID: | 10971 |
| Uniprot ID: | 1433T_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_006817.1 |
| Immunogen Sequence: | DDRKQTIDNSQ |
| Post Translational Modifications | Ser-232 is probably phosphorylated by CK1. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. |
| Protein Name | 14-3-3 Protein Theta14-3-3 Protein T-Cell14-3-3 Protein TauProtein Hs1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-9614399Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | CytoplasmIn NeuronsAxonally Transported To The Nerve Terminals |
| Alternative Antibody Names | Anti-14-3-3 Protein Theta antibodyAnti-14-3-3 Protein T-Cell antibodyAnti-14-3-3 Protein Tau antibodyAnti-Protein Hs1 antibodyAnti-YWHAQ antibody |
Information sourced from Uniprot.org
