| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
AKR1B1 Blocking Peptide for STJ500067 is synthetically produced from the 250-350 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
AKR1B1 |
| Gene ID: |
231 |
| Uniprot ID: |
ALDR_HUMAN |
| Immunogen Region: |
250-350 |
| Specificity: |
This blocking peptide is recommended for use in combination with AKR1B1 antibody, STJ500067 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-350 on human Aldo-keto reductase family 1, member B1 protein. |
| Tissue Specificity | Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). |
| Peptide Name | Aldo-Keto Reductase Family 1 Member B1 Aldehyde ReductaseAldose ReductaseAr |
| Database Links | Reactome: R-HSA-196108Reactome: R-HSA-5652227 |
| Cellular Localisation | Cytoplasm |
| Alternative Peptide Names | Aldo-Keto Reductase Family 1 Member B1 proteinAldehyde Reductase proteinAldose Reductase proteinAr proteinAKR1B1 proteinALDR1 proteinALR2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
