| Tissue Specificity | Expressed in primary and secondary lymphoid organs, where it is specifically produced by a subset of dendritic cells. Not expressed in the spleen. Constitutively expressed in thymus, as well as in the lung, skin and intestine. Not expressed in bone marrow-derived macrophages and activated B cells, nor in thymocytes. In the brain, predominantly expressed in a subset of hippocampal CA1 neurons. |
| Function | Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound. |
| Protein Name | C-C Motif Chemokine 17Abcd-2Cc Chemokine TarcSmall-Inducible Cytokine A17Thymus And Activation-Regulated Chemokine |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 17 proteinAbcd-2 proteinCc Chemokine Tarc proteinSmall-Inducible Cytokine A17 proteinThymus And Activation-Regulated Chemokine proteinCcl17 proteinTarc protein |
Information sourced from Uniprot.org
