• Human UBE2L3 (Ubiquitin Conjugating Enzyme E2L3) Sandwich ELISA Kit (STJE0012896)

Human UBE2L3 (Ubiquitin Conjugating Enzyme E2L3) Sandwich ELISA Kit (STJE0012896)

SKU:
STJE0012896

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.072ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This UBE2L3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: UBE2L3
Gene ID: 7332
Uniprot ID: UB2L3_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous, with highest expression in testis.
Post Translational Modifications Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro.
Function Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Protein Name Ubiquitin-Conjugating Enzyme E2 L3
E2 Ubiquitin-Conjugating Enzyme L3
L-Ubc
Ubch7
Ubiquitin Carrier Protein L3
Ubiquitin-Conjugating Enzyme E2-F1
Ubiquitin-Protein Ligase L3
Database Links Reactome: R-HSA-5357905
Reactome: R-HSA-5675482
Reactome: R-HSA-8866652
Reactome: R-HSA-8866654
Reactome: R-HSA-983168
Cellular Localisation Nucleus
Cytoplasm
Alternative ELISA Names Ubiquitin-Conjugating Enzyme E2 L3 ELISA kit
E2 Ubiquitin-Conjugating Enzyme L3 ELISA kit
L-Ubc ELISA kit
Ubch7 ELISA kit
Ubiquitin Carrier Protein L3 ELISA kit
Ubiquitin-Conjugating Enzyme E2-F1 ELISA kit
Ubiquitin-Protein Ligase L3 ELISA kit
UBE2L3 ELISA kit
UBCE7 ELISA kit
UBCH7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance