• Human SPTLC3 (Serine Palmitoyltransferase, Long Chain Base Subunit 3) Sandwich ELISA Kit (STJE0012330)

Human SPTLC3 (Serine Palmitoyltransferase, Long Chain Base Subunit 3) Sandwich ELISA Kit (STJE0012330)

SKU:
STJE0012330

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.058ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SPTLC3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SPTLC3
Gene ID: 55304
Uniprot ID: SPTC3_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in most tissues, except peripheral blood cells and bone marrow, with highest levels in heart, kidney, liver, uterus and skin.
Post Translational Modifications
Function Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Protein Name Serine Palmitoyltransferase 3
Long Chain Base Biosynthesis Protein 2b
Lcb2b
Long Chain Base Biosynthesis Protein 3
Lcb 3
Serine-Palmitoyl-Coa Transferase 3
Spt 3
Database Links Reactome: R-HSA-1660661
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative ELISA Names Serine Palmitoyltransferase 3 ELISA kit
Long Chain Base Biosynthesis Protein 2b ELISA kit
Lcb2b ELISA kit
Long Chain Base Biosynthesis Protein 3 ELISA kit
Lcb 3 ELISA kit
Serine-Palmitoyl-Coa Transferase 3 ELISA kit
Spt 3 ELISA kit
SPTLC3 ELISA kit
C20orf38 ELISA kit
SPTLC2L ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance