Human ITLN1/Omentin protein (Recombinant) (N-His) (STJP005762)

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STJP005762
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ITLN1/Omentin-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ITLN1
Gene ID: 55600
Uniprot ID: ITLN1_HUMAN
Immunogen Region: Cys31-Gly253
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.
Function Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption.
Protein Name Intelectin-1
Itln-1
Endothelial Lectin Hl-1
Galactofuranose-Binding Lectin
Intestinal Lactoferrin Receptor
Omentin
Database Links Reactome: R-HSA-6803157
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Enriched In Lipid Rafts
Alternative Protein Names Intelectin-1 protein
Itln-1 protein
Endothelial Lectin Hl-1 protein
Galactofuranose-Binding Lectin protein
Intestinal Lactoferrin Receptor protein
Omentin protein
ITLN1 protein
INTL protein
ITLN protein
LFR protein
UNQ640 protein
PRO1270 protein

Information sourced from Uniprot.org

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