| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.01 EU/Mu g |
| Gene Symbol: |
IL34 |
| Gene ID: |
146433 |
| Uniprot ID: |
IL34_HUMAN |
| Immunogen Region: |
Asn21-Pro242 |
| Immunogen: |
Recombinant human IL-34 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn21-Pro242) of human IL-34 (Accession #NP_689669.2) fused with and a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
NEPLEMWPLTQNEECTVTGF LRDKLQYRSRLQYMKHYFPI NYKISVPYEGVFRIANVTRL QRAQVSERELRYLWVLVSLS ATESVQDVLLEGHPSWKYLQ EVETLLLNVQQGLTDVEVSP KVESVLSLLNAPGPNLKLVR PKALLDNCFRVMELLYCSCC KQSSVLNWQDCEVPSPQSCS PEPSLQYAATQLYPPPPWSP SSPPHSTGSVRPVRAQGEGL LP |
| Function | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
| Protein Name | Interleukin-34Il-34 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-9680350 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-34 proteinIl-34 proteinIL34 proteinC16orf77 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
