| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1. |
| Protein Name | Interferon Gamma Receptor 1Ifn-Gamma Receptor 1Ifn-Gamma-R1Cdw119Interferon Gamma Receptor Alpha-ChainIfn-Gamma-R-AlphaCd Antigen Cd119 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-9679191Reactome: R-HSA-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interferon Gamma Receptor 1 proteinIfn-Gamma Receptor 1 proteinIfn-Gamma-R1 proteinCdw119 proteinInterferon Gamma Receptor Alpha-Chain proteinIfn-Gamma-R-Alpha proteinCd Antigen Cd119 proteinIFNGR1 protein |
Information sourced from Uniprot.org
