Human BMPR2 protein (Recombinant-Active) (C-His) (STJP012106)

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STJP012106-100
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Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human BMPR2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: BMPR2
Gene ID: 659
Uniprot ID: BMPR2_HUMAN
Immunogen Region: Ser27-Ile151
Immunogen: Homo sapiens (Human)
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Protein Name Bone Morphogenetic Protein Receptor Type-2
Bmp Type-2 Receptor
Bmpr-2
Bone Morphogenetic Protein Receptor Type Ii
Bmp Type Ii Receptor
Bmpr-Ii
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Bone Morphogenetic Protein Receptor Type-2 protein
Bmp Type-2 Receptor protein
Bmpr-2 protein
Bone Morphogenetic Protein Receptor Type Ii protein
Bmp Type Ii Receptor protein
Bmpr-Ii protein
BMPR2 protein
PPH1 protein

Information sourced from Uniprot.org

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