| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZWILCH (292-591) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZWILCH |
| Gene ID: |
55055 |
| Uniprot ID: |
ZWILC_HUMAN |
| Immunogen Region: |
292-591 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 292-591 of human ZWILCH (NP_060445.3). |
| Immunogen Sequence: |
AKSAVELVQEFLNDLNKLDG FGDSTKKDTEVETLKHDTAA VDRSVKRLFKVRSDLDFAEQ LWCKMSSSVISYQDLVKCFT LIIQSLQRGDIQPWLHSGSN SLLSKLIHQSYHGTMDTVSL SGTIPVQMLLEIGLDKLKKD YISFFIGQELASLNHLEYFI APSVDIQEQVYRVQKLHHIL EILVSCMPFIKSQHELLFSL TQICIKYYKQNPLDEQHIFQ LPVRPTAVKNLYQSEKPQK |
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. |
| Protein Name | Protein Zwilch HomologHzwilch |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | ChromosomeCentromereKinetochore |
| Alternative Antibody Names | Anti-Protein Zwilch Homolog antibodyAnti-Hzwilch antibodyAnti-ZWILCH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
