| Tissue Specificity | Ubiquitous. |
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. |
| Protein Name | Bub3-Interacting And Glebs Motif-Containing Protein Znf207BugzHbugzZinc Finger Protein 207 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindleLocalizes Primarily To The Nucleus In InterphaseConcentrates At Kinetochores Prior To Nuclear Envelope Breakdown And During Early PrometaphaseAnd Disappears From Kinetochores Upon Microtubule-Binding |
| Alternative Antibody Names | Anti-Bub3-Interacting And Glebs Motif-Containing Protein Znf207 antibodyAnti-Bugz antibodyAnti-Hbugz antibodyAnti-Zinc Finger Protein 207 antibodyAnti-ZNF207 antibodyAnti-BUGZ antibody |
Information sourced from Uniprot.org
