| Post Translational Modifications | Phosphorylated in vitro at Ser-22 by AURKB.however, phosphorylation at this site could not be confirmed in vivo. |
| Function | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. |
| Protein Name | Abscission/Nocut Checkpoint RegulatorAnchrMll Partner Containing Fyve DomainZinc Finger Fyve Domain-Containing Protein 19 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCleavage FurrowMidbodyMidbody RingLocalizes Mainly On Centrosomes In Interphase And Early MitosisLocalizes At The Cleavage Furrow And Midbody Ring In Late Mitosis And Cytokinesis |
| Alternative Antibody Names | Anti-Abscission/Nocut Checkpoint Regulator antibodyAnti-Anchr antibodyAnti-Mll Partner Containing Fyve Domain antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 19 antibodyAnti-ZFYVE19 antibodyAnti-ANCHR antibodyAnti-MPFYVE antibody |
Information sourced from Uniprot.org
