| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP6 (55-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP6 |
| Gene ID: |
9098 |
| Uniprot ID: |
UBP6_HUMAN |
| Immunogen Region: |
55-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 55-120 of human USP6 (NP_004496.2). |
| Immunogen Sequence: |
ELPPVTAREAKKIRREMTRT SKWMEMLGEWETYKHSSKLI DRVYKGIPMNIRGPVWSVLL NIQEIK |
| Tissue Specificity | Testis specific. Expressed in various cancer cell lines. |
| Post Translational Modifications | Monubiquitinated.ubiquitination is calmodulin and calcium dependent. |
| Function | Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 6Deubiquitinating Enzyme 6Proto-Oncogene Tre-2Ubiquitin Thioesterase 6Ubiquitin-Specific-Processing Protease 6 |
| Cellular Localisation | Cell MembraneCytoplasmEndosomeLocalizes To The Plasma Membrane And To Filamentous Structures Within The Cell Corresponding To Arf6 Regulated Tubular EndosomesActivation Of Rac1 And Cdc42 Can Direct The Relocalization Of Usp6 To The Plasma Membrane In A Manner That Depends On The Integrity Of The Actin Cytoskeleton |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 6 antibodyAnti-Deubiquitinating Enzyme 6 antibodyAnti-Proto-Oncogene Tre-2 antibodyAnti-Ubiquitin Thioesterase 6 antibodyAnti-Ubiquitin-Specific-Processing Protease 6 antibodyAnti-USP6 antibodyAnti-HRP1 antibodyAnti-TRE2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
