| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRAF1 |
| Gene ID: | 7185 |
| Uniprot ID: | TRAF1_HUMAN |
| Immunogen Region: | 217-416 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 217-416 of human TRAF1 (NP_005649.1). |
| Immunogen Sequence: | TSIHQSQLDRERILSLEQRV VELQQTLAQKDQALGKLEQS LRLMEEASFDGTFLWKITNV TRRCHESACGRTVSLFSPAF YTAKYGYKLCLRLYLNGDGT GKRTHLSLFIVIMRGEYDAL LPWPFRNKVTFMLLDQNNRE HAIDAFRPDLSSASFQRPQS ETNVASGCPLFFPLSKLQSP KHAYVKDDTMFLKCIVETST |
| Post Translational Modifications | Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation. Ubiquitinated by the SCF(FBXL2) complex, leading to its degradation by the proteasome. |
| Function | Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. |
| Protein Name | Tnf Receptor-Associated Factor 1Epstein-Barr Virus-Induced Protein 6 |
| Database Links | Reactome: R-HSA-5357905Reactome: R-HSA-5357956 |
| Alternative Antibody Names | Anti-Tnf Receptor-Associated Factor 1 antibodyAnti-Epstein-Barr Virus-Induced Protein 6 antibodyAnti-TRAF1 antibodyAnti-EBI6 antibody |
Information sourced from Uniprot.org