| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TOP2B |
| Gene ID: |
7155 |
| Uniprot ID: |
TOP2B_HUMAN |
| Immunogen Region: |
1400-1500 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human TOP2B (NP_001059.2). |
| Immunogen Sequence: |
DGEDEFVPSDGLDKDEYTFS PGKSKATPEKSLHDKKSQDF GNLFSFPSYSQKSEDDSAKF DSNEEDSASVFSPSFGLKQT DKVPSKTVAAKKGKPSSDTV P |
| Tissue Specificity | Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung. Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas. |
| Post Translational Modifications | (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1.leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. SUMOylated. |
| Function | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. |
| Protein Name | Dna Topoisomerase 2-BetaDna Topoisomerase Ii - Beta Isozyme |
| Database Links | Reactome: R-HSA-4615885 |
| Cellular Localisation | NucleusNucleolusNucleoplasm |
| Alternative Antibody Names | Anti-Dna Topoisomerase 2-Beta antibodyAnti-Dna Topoisomerase Ii - Beta Isozyme antibodyAnti-TOP2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
