| Tissue Specificity | Expressed in brain, heart, kidney, lung and skeletal muscle. |
| Post Translational Modifications | Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA. |
| Function | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. |
| Protein Name | Nucleolysin TiarTia-1-Related Protein |
| Database Links | Reactome: R-HSA-6803529 |
| Cellular Localisation | NucleusCytoplasmCytolytic GranuleStress GranuleNuclear Import Seems To Be Coupled To Rna Polymerase Ii Transcription And May Be Dependent On Rna-BindingAccumulates In Cytoplasmic Stress Granules (Sg) Following Cellular Damage |
| Alternative Antibody Names | Anti-Nucleolysin Tiar antibodyAnti-Tia-1-Related Protein antibodyAnti-TIAL1 antibody |
Information sourced from Uniprot.org
