| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TENM1 (350-540) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TENM1 |
| Gene ID: |
10178 |
| Uniprot ID: |
TEN1_HUMAN |
| Immunogen Region: |
350-540 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-540 of human TENM1 (NP_001156750.1). |
| Immunogen Sequence: |
QPVEGELYANGVSKGNRGTE SMDTTYSPIGGKVSDKSEKK VFQKGRAIDTGEVDIGAQVM QTIPPGLFWRFQITIHHPIY LKFNISLAKDSLLGIYGRRN IPPTHTQFDFVKLMDGKQLV KQDSKGSDDTQHSPRNLILT SLQETGFIEYMDQGPWYLAF YNDGKKMEQVFVLTTAIEIM DDCSTNCNGNG |
| Tissue Specificity | Expressed in fetal brain. |
| Post Translational Modifications | Teneurin C-terminal-associated peptide: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated. |
| Function | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer. Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking. Ten-1 intracellular domain: Induces gene transcription activation. |
| Protein Name | Teneurin-1Ten-1Protein Odd Oz/Ten-M Homolog 1Tenascin-M1Ten-M1Teneurin Transmembrane Protein 1 Cleaved Into - Ten-1 Intracellular DomainIdten-1Ten-1 Icd - Teneurin C-Terminal-Associated PeptideTcpa-1Ten-1 Extracellular DomainTen-1 Ecd |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinTen-1 Intracellular Domain: NucleusNucleus SpeckleNucleus MatrixCytoplasmCytoskeletonTeneurin C-Terminal-Associated Peptide: NucleusColocalizes With The Dystroglycan Complex At The Cell Membrane In Hippocampal CellsBinds Hippocampal Cell Membranes And Is Incorporated In The Cytoplasm By Endocytosis In A Caveoli-Dependent MannerUpon Cell Internalization Is Transported Arround And In The Nucleus |
| Alternative Antibody Names | Anti-Teneurin-1 antibodyAnti-Ten-1 antibodyAnti-Protein Odd Oz/Ten-M Homolog 1 antibodyAnti-Tenascin-M1 antibodyAnti-Ten-M1 antibodyAnti-Teneurin Transmembrane Protein 1 Cleaved Into - Ten-1 Intracellular Domain antibodyAnti-Idten-1 antibodyAnti-Ten-1 Icd - Teneurin C-Terminal-Associated Peptide antibodyAnti-Tcpa-1 antibodyAnti-Ten-1 Extracellular Domain antibodyAnti-Ten-1 Ecd antibodyAnti-TENM1 antibodyAnti-ODZ1 antibodyAnti-TNM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
