| Tissue Specificity | Expressed in fetal brain. |
| Post Translational Modifications | Teneurin C-terminal-associated peptide: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated. |
| Function | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer. Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking. Ten-1 intracellular domain: Induces gene transcription activation. |
| Protein Name | Teneurin-1Ten-1Protein Odd Oz/Ten-M Homolog 1Tenascin-M1Ten-M1Teneurin Transmembrane Protein 1 Cleaved Into - Ten-1 Intracellular DomainIdten-1Ten-1 Icd - Teneurin C-Terminal-Associated PeptideTcpa-1Ten-1 Extracellular DomainTen-1 Ecd |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinTen-1 Intracellular Domain: NucleusNucleus SpeckleNucleus MatrixCytoplasmCytoskeletonTeneurin C-Terminal-Associated Peptide: NucleusColocalizes With The Dystroglycan Complex At The Cell Membrane In Hippocampal CellsBinds Hippocampal Cell Membranes And Is Incorporated In The Cytoplasm By Endocytosis In A Caveoli-Dependent MannerUpon Cell Internalization Is Transported Arround And In The Nucleus |
| Alternative Antibody Names | Anti-Teneurin-1 antibodyAnti-Ten-1 antibodyAnti-Protein Odd Oz/Ten-M Homolog 1 antibodyAnti-Tenascin-M1 antibodyAnti-Ten-M1 antibodyAnti-Teneurin Transmembrane Protein 1 Cleaved Into - Ten-1 Intracellular Domain antibodyAnti-Idten-1 antibodyAnti-Ten-1 Icd - Teneurin C-Terminal-Associated Peptide antibodyAnti-Tcpa-1 antibodyAnti-Ten-1 Extracellular Domain antibodyAnti-Ten-1 Ecd antibodyAnti-TENM1 antibodyAnti-ODZ1 antibodyAnti-TNM1 antibody |
Information sourced from Uniprot.org
