| Tissue Specificity | Isoform 1: Found in neonatal brain, and in a wide variety of adult non-neuronal tissues. Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Also detected in the lung and heart. Expressed at higher levels than isoform 2 in the testis and liver and is not detected in the skeletal muscle. Isoform 2: Expressed predominantly in the neurons, but is also found in all other tissues at much lower levels. Also detected in the lung and heart. Epressed at lower levels than isoform 1 in the testis and liver and is not detected in the skeletal muscle. Isoform 3: Expressed in the brain. |
| Function | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. |
| Protein Name | Synaptojanin-1Synaptic Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 1 |
| Database Links | Reactome: R-RNO-1660499Reactome: -RNO-1855183Reactome: -RNO-1855204Reactome: -RNO-8856828 |
| Cellular Localisation | Isoform 1: MembraneCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Synaptojanin-1 antibodyAnti-Synaptic Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 1 antibodyAnti-Synj1 antibody |
Information sourced from Uniprot.org
