| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ST8SIA4 |
| Gene ID: |
7903 |
| Uniprot ID: |
SIA8D_HUMAN |
| Immunogen Region: |
20-168 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of human ST8SIA4 (NP_778222.1). |
| Immunogen Sequence: |
YKTKEIARTEEHQETQLIGD GELSLSRSLVNSSDKIIRKA GSSIFQHNVEGWKINSSLVL EIRKNILRFLDAERDVSVVK SSFKPGDVIHYVLDRRRTLN ISHDLHSLLPEVSPMKNRRF KTCAVVGNSGILLDSECGKE IDSHNFVIR |
| Tissue Specificity | Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes. |
| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid. |
| Protein Name | Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-SialyltransferaseAlpha-2 -8-Sialyltransferase 8dPolysialyltransferasePolysialyltransferase-1Sialyltransferase 8dSiat8-DSialyltransferase St8sia IvSt8siaiv |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecreted |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-Sialyltransferase antibodyAnti-Alpha-2 -8-Sialyltransferase 8d antibodyAnti-Polysialyltransferase antibodyAnti-Polysialyltransferase-1 antibodyAnti-Sialyltransferase 8d antibodyAnti-Siat8-D antibodyAnti-Sialyltransferase St8sia Iv antibodyAnti-St8siaiv antibodyAnti-ST8SIA4 antibodyAnti-PST antibodyAnti-PST1 antibodyAnti-SIAT8D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and CDKN2C/p18-INK4C knockout (KO) HeLa cells, using [KO Validated] CDKN2C/p18-INK4C Rabbit polyclonal antibody (STJ11100027) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89099/357558/STJ11100027_1__55104.1713121682.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and CDKN2C/p18-INK4C knockout (KO) HeLa cells, using [KO Validated] CDKN2C/p18-INK4C Rabbit polyclonal antibody (STJ11100027) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.")
