• Western blot analysis of lysates from wild type (WT) and CDKN2C/p18-INK4C knockout (KO) HeLa cells, using [KO Validated] CDKN2C/p18-INK4C Rabbit polyclonal antibody (STJ11100027) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CDKN2C antibody (1-168) (STJ11100027)

SKU:
STJ11100027

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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDKN2C/p18-INK4C (1-168) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDKN2C
Gene ID: 1031
Uniprot ID: CDN2C_HUMAN
Immunogen Region: 1-168
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (NP_523240.1).
Immunogen Sequence: MAEPWGNELASAAARGDLEQ LTSLLQNNVNVNAQNGFGRT ALQVMKLGNPEIARRLLLRG ANPDLKDRTGFAVIHDAARA GFLDTLQTLLEFQADVNIED NEGNLPLHLAAKEGHLRVVE FLVKHTASNVGHRNHKGDTA CDLARLYGRNEVVSLMQANG AGGATNLQ
Tissue Specificity Highest levels found in skeletal muscle. Also found in pancreas and heart.
Function Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Protein Name Cyclin-Dependent Kinase 4 Inhibitor C
Cyclin-Dependent Kinase 6 Inhibitor
P18-Ink4c
P18-Ink6
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-2559582
Reactome: R-HSA-2559585
Reactome: R-HSA-69231
Alternative Antibody Names Anti-Cyclin-Dependent Kinase 4 Inhibitor C antibody
Anti-Cyclin-Dependent Kinase 6 Inhibitor antibody
Anti-P18-Ink4c antibody
Anti-P18-Ink6 antibody
Anti-CDKN2C antibody
Anti-CDKN6 antibody

Information sourced from Uniprot.org

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