Anti-SLC19A1 antibody (452-591) (STJ116850)

SKU:
STJ116850

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC19A1 (452-591) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC19A1
Gene ID: 6573
Uniprot ID: S19A1_HUMAN
Immunogen Region: 452-591
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 452-591 of human SLC19A1 (NP_919231.1).
Immunogen Sequence: LDGLRHCQRGHHPRQPPAQG LRSAAEEKAAQALSVQDKGL GGLQPAQSPPLSPEDSLGAV GPASLEQRQSDPYLAQAPAP QAAEFLSPVTTPSPCTLCSA QASGPEAADETCPQLAVHPP GVSKLGLQCLPSDGVQNVNQ
Tissue Specificity Placenta, liver, and to a much smaller extent, in lung.
Function Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity.
Protein Name Reduced Folate Transporter
Folt
Cyclic Dinucleotide -Anion Antiporter Slc19a1
Folate -Anion Antiporter Slc19a1
Intestinal Folate Carrier 1
Ifc-1
Placental Folate Transporter
Reduced Folate Carrier Protein
Rfc
Hrfc
Reduced Folate Transporter 1
Rft-1
Solute Carrier Family 19 Member 1
Hslc19a1
Database Links Reactome: R-HSA-196757
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Basolateral Cell Membrane
Alternative Antibody Names Anti-Reduced Folate Transporter antibody
Anti-Folt antibody
Anti-Cyclic Dinucleotide -Anion Antiporter Slc19a1 antibody
Anti-Folate -Anion Antiporter Slc19a1 antibody
Anti-Intestinal Folate Carrier 1 antibody
Anti-Ifc-1 antibody
Anti-Placental Folate Transporter antibody
Anti-Reduced Folate Carrier Protein antibody
Anti-Rfc antibody
Anti-Hrfc antibody
Anti-Reduced Folate Transporter 1 antibody
Anti-Rft-1 antibody
Anti-Solute Carrier Family 19 Member 1 antibody
Anti-Hslc19a1 antibody
Anti-SLC19A1 antibody
Anti-FLOT1 antibody
Anti-RFC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance