| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SKIV2L2 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTREX |
| Gene ID: |
23517 |
| Uniprot ID: |
MTREX_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SKIV2L2 (NP_056175.3). |
| Immunogen Sequence: |
MADAFGDELFSVFEGDSTTA AGTKKDKEKDKGKWKGPPGS ADKAGKRFDGKLQSESTNNG KNKRDVDFEGTDEPIFGKKP RIEESITEDLSLADLMPRVK VQSVETVEGCTHEVALPAEE DYLPLKPRVGKAAKEYPFIL DAFQREAIQCVDNNQSVLVS AHTSAGKTVCAEYAIALALR EKQRVIFTSPIKALSNQKYR EMYEEFQDVGLMTGDVTINP TASCLVMTTEILRSMLYRG |
| Function | Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex. Plays a role in DNA damage response. |
| Protein Name | Exosome Rna Helicase Mtr4Atp-Dependent Rna Helicase Dob1Atp-Dependent Rna Helicase Skiv2l2Superkiller Viralicidic Activity 2-Like 2Tramp-Like Complex Helicase |
| Database Links | Reactome: R-HSA-6791226Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmNucleolusNucleus Speckle |
| Alternative Antibody Names | Anti-Exosome Rna Helicase Mtr4 antibodyAnti-Atp-Dependent Rna Helicase Dob1 antibodyAnti-Atp-Dependent Rna Helicase Skiv2l2 antibodyAnti-Superkiller Viralicidic Activity 2-Like 2 antibodyAnti-Tramp-Like Complex Helicase antibodyAnti-MTREX antibodyAnti-DOB1 antibodyAnti-KIAA0052 antibodyAnti-MTR4 antibodyAnti-SKIV2L2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
