| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRKX (239-358) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRKX |
| Gene ID: |
5613 |
| Uniprot ID: |
PRKX_HUMAN |
| Immunogen Region: |
239-358 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 239-358 of human PRKX (NP_005035.1). |
| Immunogen Sequence: |
SGFPPFFDDNPFGIYQKILA GKIDFPRHLDFHVKDLIKKL LVVDRTRRLGNMKNGANDVK HHRWFRSVDWEAVPQRKLKP PIVPKIAGDGDTSNFETYPE NDWDTAAPVPQKDLEIFKNF |
| Tissue Specificity | Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes. |
| Post Translational Modifications | Phosphorylated.autophosphorylates in vitro. |
| Function | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. |
| Protein Name | Camp-Dependent Protein Kinase Catalytic Subunit PrkxPrkxProtein Kinase XProtein Kinase X-LinkedSerine/Threonine-Protein Kinase PrkxProtein Kinase Pkx1 |
| Database Links | Reactome: R-HSA-111931Reactome: R-HSA-442720Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | CytoplasmNucleusCamp Induces Nuclear Translocation |
| Alternative Antibody Names | Anti-Camp-Dependent Protein Kinase Catalytic Subunit Prkx antibodyAnti-Prkx antibodyAnti-Protein Kinase X antibodyAnti-Protein Kinase X-Linked antibodyAnti-Serine/Threonine-Protein Kinase Prkx antibodyAnti-Protein Kinase Pkx1 antibodyAnti-PRKX antibodyAnti-PKX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
