| Post Translational Modifications | Ubiquitinated by RNF220 that leads to proteasomal degradation. |
| Function | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. |
| Protein Name | Paired Amphipathic Helix Protein Sin3bHistone Deacetylase Complex Subunit Sin3bTranscriptional Corepressor Sin3b |
| Database Links | Reactome: R-HSA-400206 O75182-1Reactome: R-HSA-427413Reactome: R-HSA-8936459Reactome: R-HSA-9707564 O75182-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Amphipathic Helix Protein Sin3b antibodyAnti-Histone Deacetylase Complex Subunit Sin3b antibodyAnti-Transcriptional Corepressor Sin3b antibodyAnti-SIN3B antibodyAnti-KIAA0700 antibody |
Information sourced from Uniprot.org
