| Host: |
Rabbit |
| Applications: |
WB/IF/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RUVBL2 (1-463) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200IP 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RUVBL2 |
| Gene ID: |
10856 |
| Uniprot ID: |
RUVB2_HUMAN |
| Immunogen Region: |
1-463 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-463 of human Reptin/Reptin/RUVBL2 (NP_006657.1). |
| Immunogen Sequence: |
MATVTATTKVPEIRDVTRIE RIGAHSHIRGLGLDDALEPR QASQGMVGQLAARRAAGVVL EMIREGKIAGRAVLIAGQPG TGKTAIAMGMAQALGPDTPF TAIAGSEIFSLEMSKTEALT QAFRRSIGVRIKEETEIIEG EVVEIQIDRPATGTGSKVGK LTLKTTEMETIYDLGTKMIE SLTKDKVQAGDVITIDKATG KISKLGRSFTRARDYDAMGS QTKFVQCPDGELQKRKEVV |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in testis and thymus. |
| Function | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity.hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. May play a role in regulating the composition of the U5 snRNP complex. |
| Protein Name | Ruvb-Like 248 Kda Tata Box-Binding Protein-Interacting Protein48 Kda Tbp-Interacting Protein51 Kda Erythrocyte Cytosolic ProteinEcp-51Ino80 Complex Subunit JRepressing Pontin 52Reptin 52Tip49bTip60-Associated Protein 54-BetaTap54-Beta |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus MatrixNucleusNucleoplasmCytoplasmMembraneDynein Axonemal ParticleMainly Localized In The NucleusAssociated With Nuclear Matrix Or In The Nuclear CytosolAlthough It Is Also Present In The Cytoplasm And Associated With The Cell Membranes |
| Alternative Antibody Names | Anti-Ruvb-Like 2 antibodyAnti-48 Kda Tata Box-Binding Protein-Interacting Protein antibodyAnti-48 Kda Tbp-Interacting Protein antibodyAnti-51 Kda Erythrocyte Cytosolic Protein antibodyAnti-Ecp-51 antibodyAnti-Ino80 Complex Subunit J antibodyAnti-Repressing Pontin 52 antibodyAnti-Reptin 52 antibodyAnti-Tip49b antibodyAnti-Tip60-Associated Protein 54-Beta antibodyAnti-Tap54-Beta antibodyAnti-RUVBL2 antibodyAnti-INO80J antibodyAnti-TIP48 antibodyAnti-TIP49B antibodyAnti-CGI-46 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
